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Kamis, 31 Mei 2012

Male Infertility: Diagnosis and Treatment, 1st ed. 2007

Male Infertility: Diagnosis and Treatment

Thinus F. Kruger and Sergio Oehninger

ISBN-10: 0415397421

ISBN-13: 978-0415397421

Male factor infertility is a common problem in reproductive medicine and can have a significant effect of the outcome of IVF treatment. This comprehensive book covers the diagnosis and treatment of male factor infertility in depth. It opens with a section on the basic science underlying the production of male gametes. There is then a major section on diagnosis that will prove very useful to a wide range of andrologists, endocrinologists, and REIs faced with unpicking the problems facing infertile couples. The final section addresses management of the subfertile male, including endocrinologic, surgical, and ART interventions. The book is authored by a prestigious, international team of contributors.

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Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice, 1st ed. 2011

Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice

(Cambridge Medicine)

David K. Gardner, Botros R. M. B. Rizk and Tommaso Falcone

ISBN-10: 1107001129

ISBN-13: 978-1107001121

Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view of clinically relevant information and looks ahead to how practice will change over the next five years. The clinical section discusses advances in reproductive surgery and current use of robotic surgery for tubal reversal and removal of fibroids. It looks into the refinement of surgical procedures for fertility preservation purposes. Chapters also discuss non-invasive diagnosis of endometriosis with proteomics technology, new concepts in ovarian stimulation and in the management of polycystic ovary syndrome, and evidence-based ART. The embryology section discusses issues ranging from three-dimensional in-vitro ovarian follicle culture, and morphometric and proteomics analysis of embryos, to oocyte and embryo cyropreservation. This forward-looking volume of review articles is key reading for reproductive medicine physicians, gynecologists, reproductive endocrinologists, urologists and andrologists.

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Basal Cell Carcinoma 2012

Vishal Madan

The authors have to be commended on presenting their research on several aspects of basal cell carcinoma in a succinct manner, which shall not only enhance our understanding of, but also hopefully via this open exchange of ideas pave ways for successful targeted therapy of the commonest human cancer.

Basal cell carcinoma is the commonest cutaneous malignancy. The last decade has witnessed exponential research which has broadened our understanding of the pathogenesis of basal cell carcinomas. This is also important from a therapeutic point of view as targeted approach to therapy is now being increasingly experimented.

Contents
Preface
1 Custom Made Mold Brachytherapy
2 Molecularbiology of Basal Cell Carcinoma
3 BCC and the Secret Lives of Patched: Insights from Patched Mouse Models
4 The Role of Cytokines and Chemokines in the Development of Basal Cell Carcinoma
5 Metastatic Basal Cell Carcinoma
6 Genomics of Basal and Squamous Cell Carcinomas

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First Exposure to General Surgery

(LANGE First Exposure)

Danny Jacobs

ISBN-10: 0071441409

ISBN-13: 978-0071441407

FIRST EXPOSURE: To GENERAL SURGERY enhances your rotation with:

A compelling profile of the practice of general surgery
Just the right amount of material for your 4-week clerkship
Detailed descriptions of procedures you will see and perform
A focus on important concepts you should learn-not memorization of facts
How-to's for evaluating the surgical patient
Clinically relevant detail on cases you will see

FIRST EXPOSURE SERIES BOOKS PHYSICIANS WISH THEY HAD IN THEIR CLERKSHIPS

Just the right amount of information to read and absorb during your clerkship
An orientation to each specialty and the ways it differs from other specialties
What you can expect to get from your clerkship
Clinically helpful information on the procedures you will see and perform
A breakdown of the "Chief Complaints" you are most likely to encounter, with a table of "Don't-Miss Diagnoses"
Essential information on common diseases and conditions seen in each specialty Adding value to the clerkship experience-that's what First Exposure is all about.

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Analgesia, Anaesthesia and Pregnancy: A Practical Guide

Steve Yentis, Anne May and Surbhi Malhotra

ISBN-10: 0521694744

ISBN-13: 978-0521694742

A thoroughly updated edition of this well-established practical guide to obstetric analgesia and anaesthesia originally published by W. B. Saunders. All aspects of obstetric medicine relevant to the anaesthetist are covered, from conception, throughout pregnancy, to after birth care. The emphasis is on pre-empting problems and maximising quality of care. The authors have identified over 150 potential complications each covered in two sections: issues raised and management options, with key points extracted into boxes for quick reference. A section on organisational aspects such as record keeping, training, protocols and guidelines makes this an important resource for any labour ward or hospital dealing with pregnant women. Presented in a clear, structured format, this book will be invaluable to trainee anaesthetists at all levels and to experienced anaesthetists who encounter obstetric patients. Obstetricians, neonatologists, midwives, nurses and operating department practitioners wishing to extend or update their knowledge will also find it highly beneficial.

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A Handbook for Medical Teachers, 4th ed. 2002

A Handbook for Medical Teachers

D. I. Newble and R. A. Cannon

ISBN-10: 9048157420

ISBN-13: 978-9048157426

This is the extensively revised 4th edition of a popular handbook It offers a successful combination of sound educational principles, a how-to-do-it approach and an entertaining easy-to-read style, and contains numerous illustrations, examples, and pertinent cartoons. This fourth edition has been revised to reflect the major changes that continue to occur in both undergraduate and postgraduate education.

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Illustrated Textbook of Paediatrics, 3rd ed. 2007

Tom Lissauer and Graham Clayden

ISBN-10: 0723433976

ISBN-13: 978-0723433972

A concise, colourfully illustrated and highly informative textbook of paediatrics. Written primarily for medical students for their course in clinical paediatrics (6-10 weeks in duration in the UK and worldwide), the book has found a wider audience among nurses, trainee paediatricians preparing for the MRCPCH, and general practitioners preparing for the DCH. Throughout, there is an emphasis on the core fundamentals of paediatrics practice throughout the world, which has contributed to its success in Europe, Asia, Australia and the Middle East.

In the book:

Summary boxes to help learning/revision
Additional diagrams and photographs to assist learning
Bringing book up to date and expanding topical items such as immunisations, obesity, child protection, ethics, medicines in children
New chapters on Allergy and Adolescent Medicine
Improved navigation by means of: Chapter summaries at the beginning of chapters using main headings and page numbers
Colour-coding of chapters
Differentiation of types of boxes by colour and numbering..

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Diagnostic and Therapeutic Advances in Hematologic Malignancies

(Cancer Treatment and Research)

Martin S. Tallman and Leo I. Gordon

ISBN-10: 0792382064

ISBN-13: 978-0792382065

There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constantly evolving concepts in this area.

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Clinical Aspects and Laboratory. Iron Metabolism, Anemias: Concepts in the anemias of malignancies and renal and rheumatoid diseases, 6th ed. 2011

Clinical Aspects and Laboratory. Iron Metabolism, Anemias: Concepts in the anemias of malignancies and renal and rheumatoid diseases

Manfred Wick, Wulf Pinggera and Paul Lehmann

ISBN-10: 3709100860

ISBN-13: 978-3709100868

Iron is essential for most forms of life, including humans. On the other hand, iron is also potentially toxic. Therefore, the control of iron metabolism and maintenance of iron hemostasis is an crucial part of many aspects of human health and disease. Iron deficiency anemia is one of the most common diseases worldwide, but there are also anemias associated with chronic diseases, and other acquired or hereditary defects. Understanding the control of iron metabolism is furthermore important for understanding diseases of iron overload, like hemochromatosis. This booklet is designed for physicians, clinical lab personnel and medical students. It gives an overview about the principles of regulation of iron metabolism and erythropoiesis. In addition, the various disturbances of iron metabolism and the associated clinical findings are described. Special focus lies on the differential diagnosis of the disorders, and the approaches of therapy. Finally, a comprehensive schedule of tests is included available for the determination of iron metabolism-related parameters in serum/plasma and blood, with indication of methodologies applied and reference ranges.

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CT and MRI of the Abdomen and Pelvis: A Teaching File, 2nd ed. 2007

CT and MRI of the Abdomen and Pelvis: A Teaching File

(LWW Teaching File Series),

Pablo R. Ros, Koenraad J. Mortele, Sylvester Lee, Vincent Pelsser

ISBN-10: 0781772370

ISBN-13: 978-0781772372

Featuring 1,785 CT and MRI images and 470 cases from leading medical centers, this Second Edition is a comprehensive teaching-file atlas covering virtually all abdominal and pelvic diseases. Cases are presented as unknowns in a consistent format—a brief clinical history, several images, relevant findings, differential diagnosis, final diagnosis, and a discussion. This format helps readers hone their diagnostic reasoning skills and offers excellent preparation for radiology board exams. This edition includes 245 brand-new cases, new images for 190 cases, and a new abdominal wall chapter. Images reflect state-of-the-art technologies, including multidetector row CT, 3D reformatted images, and breath-hold MRI sequences.

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Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use, 1st ed. 2012

Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use

(Milestones in Drug Therapy)

Henry M. Staines and Sanjeev Krishna

ISBN-10: 3034604793

ISBN-13: 978-3034604796

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

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Ob / Gyn Secrets, Updated 3rd Edition

Thomas Bader

ISBN-10: 0323034152

ISBN-13: 978-0323034159

The Secrets Series® is breaking new ground again. This volume in the very popular Secrets Series® is back in an exciting, updated, and completely redesigned 3rd Edition. A new, two-color page layout, a more portable size, and a list of the "Top 100 Secrets" in obstetrics and gynecology help readers to better meet the challenges they face today. And, at no extra charge, purchasers also receive online access to the complete contents of the text via Elsevier's innovative STUDENTConsult.com website. Readers will still find all of the features they rely on the Secret Series® for-a question- and -answer format, lists, mnemonics, and tables and an informal tone that make reference fast and easy. No matter what questions arise in practice or while preparing for boards, this updated 3rd Edition has the answers-in print and online.

The smart way to study!

Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

Uses bulleted lists, tables, short answers, and a highly detailed index to expedite reference.
Features pearls, tips, memory aids, and "secrets" from the experts.
Covers all of today's most common procedures and techniques.

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Molecular Pathogenesis of MODYs

American Diabetes Association Symposium. Scottsdale, Ariz., Usa, November 6-8, 1998

M. A. Magnuson and F. M. Matschinsky

ISBN-10: 3805569505

ISBN-13: 978-3805569507

A timely collection of research papers by 18 leading scientists in the area of biochemical genetics of diabetes mellitus, these contributions focus on a well defined class of monogenic forms of the disease (i.e. MODYs 1-5) all caused by specific mutations or deletion of genes that control pancreatic beta-cell functions: HNF-4alpha, glucokinase, HNF-1alpha, IDX-1 and HNF-1beta. This volume offers a historical perspective of MODYs, and it also contains contributions which deal with the fundamental questions of pancreas and liver development, critical for the understanding of the syndrome complex discussed. Attempts have been made to highlight results and concepts that may be relevant for understanding type-II diabetes in general, exemplified by contributions that connect the field of pancreatic islet cell biology and pathology with the newest findings in the area of insulin action, e.g. the role of the insulin receptor and insulin receptor substrates (IRS 1-3).

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Inflammatory Bowel Disease: Advances in Pathogenesis and Management 2012

Sami Karoui

This book is dedicated to inflammatory bowel disease, and the authors discuss the advances in the pathogenesis of inflammatory bowel disease, as well as several new parameters involved in the etiopathogeny of Crohn's disease and ulcerative colitis, such as intestinal barrier dysfunction and the roles of TH 17 cells and IL 17 in the immune response in inflammatory bowel disease.

The book also focuses on several relevant clinical points, such as pregnancy during inflammatory bowel disease and the health-related quality of life as an end point of the different treatments of the diseases. Finally, advances in management of patients with inflammatory bowel disease are discussed, especially in a complete review of the recent literature.

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Breast Calcification: A Diagnostic Manual

Andy Evans, Ian Ellis, Sarah Pinder and Robin Wilson

ISBN-10: 1841101117

ISBN-13: 978-1841101118

Screening for breast cancer is now an accepted part of healthcare practice in many parts of the world. However, the advent of mass screening has brought with it the need for rapid and accurate diagnosis. Breast calcifications in particular are commonly misinterpreted, and definitive diagnosis of whether such calcifications represent benign or malignant conditions is extremely difficult, as the calcifications can easily be missed, or their shape (which is critical in diagnosis) misinterpreted. This book aims to provide a practical understanding to the diagnosis and treatment of breast calcification and will be essential reading for all members of the breast screening team, including pathologists, radiologists and surgeons. The multidisciplinary group of authors first cover in detail the main pathologies that present with calcification, and go on to describe the techniques of fine needle aspiration and core biopsy and large bore biopsy sampling of tissue, reporting procedures, radiological management of calcification and clinical aspects of the diagnosis of breast calcification. The second part of the book looks at some of the most recently adopted methodologies for diagnosis such as high frequency ultrasound, computer aided diagnosis and the roles of MRI and synchrotron radiation.

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Medicine Recall (Recall Series)

James D. Bergin

ISBN-10: 1605476757

ISBN-13: 978-1605476759

Written primarily for third- and fourth-year medical students in clerkships, Medicine Recall, Fourth Edition covers the core specialty areas within internal medicine: cardiology, pulmonology, nephrology, gastroenterology, hematology, oncology, infectious disease, endocrinology, allergy and immunology, rheumatology, neurology, and dermatology. The book is written in the rapid-fire Recall Series question-and-answer format, with the question on the left side of the page and the answer on the right. Mnemonics are interspersed throughout. Each chapter is written by faculty, students, and fellows and emphasizes diagnosis and treatment.

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Color Atlas of Genetics, 3rd ed. 2007

Eberhard Passarge,

ISBN-13:978-3-13-100363-8

The aim of this book is to give an account of the scientific field of genetics based on visual displays of selected concepts and related facts. Additional information is presented in the introduction, with a chronological list of important discoveries and advances in the history of genetics, in an appendix with supplementary data in tables, in an extensive glossary explaining genetic terms, and in references, including web sites for further in-depth studies.

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Autopsy Room: CD-ROM

S. Cross, R. Start, D. Cotton

ISBN-10: 9057021641

ISBN-13: 978-9057021640

Many doctors will issue death certificates at some point in their career. It is crucial to establish the cause of death accurately to avoid medicolegal problems, undue distress for the relatives and embarassment for the doctor. Autopsy Room holds 30 bodies awaiting death certification. Following a brief patient history, the user must investigate each body system for pathological signs in order to determine the cause of death. Microscopic slides, radiographs and results of laboratory tests are also included. Each case fully illustrated with normal and pathological tissues.

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Avery's Diseases of the Newborn 9th ed. 2012

Christine A. Gleason and Sherin Devaskar

ISBN-10: 1437701345

ISBN-13: 978-1437701340

Avery's Diseases of the Newborn, edited by Christine A. Gleason and Sherin U. Devaskar, is a practical, clinical reference for diagnosing and managing of all the important diseases affecting newborns. Thoroughly revised by a team of new editors, this edition provides new perspectives and updated coverage of genetics, nutrition, respiratory conditions, MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and more. You can also access the fully searchable text and downloadable images online at www.expertconsult.com, making this authoritative reference ideal as a clinical resource or subspecialty review tool.

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ENT Secrets, 3rd ed, 2007

ENT Secrets

Bruce W. Jafek and Bruce W. Murrow

ISBN-10: 1560536179

ISBN-13: 978-1560536178

This new edition of one of the most popular books in otolaryngology is now completely updated and expanded. In 89 chapters, the authors cover every virtually every ENT disorder in the clear and engaging "textbook in question and answer" format of The Secrets Series(r). Ideal for rounds, clinical discussions, examinations, and a great refresher for practitioners * Includes 3 new chapters - Deafness, Hair Transplantation, and Telemedicine. * Each chapter will feature a "sidebar" - a small box of interesting history or arcana. * All the most important "need-to-know" questions-and-answers in the proven format of the highly acclaimed Secrets Series(r) * Concise answers that include the author's pearls, tips, memory aids, and "secrets" * Bulleted lists, algorithms, and illustrations for quick review * Thorough, highly detailed index * Thought-provoking questions that provide succinct answers * Presentation of a vast amount of information, but not overly simplistic

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Ophthalmic Drugs: Diagnostic and Therapeutic Uses

Graham Hopkins and Richard M. Pearson

ISBN-10: 0750688645

ISBN-13: 978-0750688642

Completely updated and revised, this classic book provides the essential information on ocular therapeutics for the modern optometrist. Retaining all the features that made previous editions so popular, the new fifth edition continues to provide a basic grounding in pharmacological principles and drug types, before moving on to illustrate the scope of ocular therapeutics in the management of common acute conditions affecting the anterior segment of the eye. Throughout the text there are numerous new clinical notes and ready-reference tables, making for greater ease of use than ever before.

Greatly expanded text including an illustrated section on ocular disease and its treatment
New drugs included, processes and procedures updated and revised
Now all completely redesigned in full colour throughout
Features ready-reference tables and clinical notes
Completely updated and revised to reflect modern practice
Clinically orientated and appropriate for the practitioner as well as the student
Written by experts with years of practical experience in teaching and training as well as dispensing these essential preparations

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Soft Tissue Rheumatology, 1st ed. 2004

Soft Tissue Rheumatology

Brian Hazleman, Graham Riley and Cathy Speed

ISBN-10: 0192630938

ISBN-13: 978-0192630933

This is a beautifully illustrated, up to date text dealing with the clinical and scientific aspects of soft tissue complaints including disorders of the tendon, ligament, bursa, fascia, muscle and nerve. The book is written by leading specialists in the fields of rheumatology, orthopaedics, radiology and rehabilitation. It is suitable for all professionals who deal with musculoskeletal complaints, primarily rheumatologists, orthopaedic surgeons and physiotherapists. Primary care physicians, musculoskeletal specialists, radiologists, sports scientists and scientists with an interest in tendon and ligament science will also find the book of value. The book covers basic science, clinical evaluation, investigations, principles of management with detailed chapters on specific regional and generalised disorders. Richly illustrated in full colour and clearly written, Soft Tissue Rheumatism is an in depth source of information on the nature, diagnosis and management of common causes of musculoskeletal pain, specifically soft tissue disorders. surgeons and physiotherapists.

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Anemia 2012

Donald S. Silverberg

This book provides an up- to- date summary of many advances in our understanding of anemia, including its causes and pathogenesis, methods of diagnosis, and the morbidity and mortality associated with it. Special attention is paid to the anemia of chronic disease. Nutritional causes of anemia, especially in developing countries, are discussed. Also presented are anemias related to pregnancy, the fetus and the newborn infant.

Thus this book provides a wide coverage of anemia which should be useful to those involved in many fields of anemia from basic researchers to epidemiologists to clinical practitioners.

Contents
1 Morbidity and Mortality in Anemia
2 Erythrocyte: Programmed Cell Death
3 Phosphatidylserine Shedding from RBCs - A Mechanism of Membrane Modulation and Damage Control
4 Anemia Caused by Oxidative Stress
5 Iron and Nitric Oxide in Anemia of Chronic Disease (ACD)
6 Diagnostic Evaluation of Anaemia
7 How Can Cancer-Associated Anemia Be Moderated with Nutritional Factors and How Do Beta Vulgaris L. Ssp. Esculenta Var. Rubra Modify the Transmethylation Reaction in Erythrocytes in Cancerous Patients?
8 Anaemia in Developing Countries: Burden and Prospects of Prevention and Control
9 Nutritional Anaemia
10 Nutritional Anemia in Developing Countries
11 Risk Factors for Anemia in Preschool Children in Sub-Saharan Africa
12 Acceptance and Effect of Ferrous Fumarate Containing Micronutrient Sprinkles on Anemia, Iron Deficiency and Anthropometries in Honduran Children
13 Supplementation and Change of Nutritional Habits for the Prevention and Treatment of Iron Deficiency Anaemia in Gaza Children: A Case Study
14 Managementof Anaemia in Pregnancy
15 Clinical Management of Hemolytic Disease of the Newborn and Fetus
16 The Pathogenesis of Anaemia in African Animal Trypanosomosis
17 The Mechanisms of Anaemia in Trypanosomosis: A Review
18 Severe Malaria Anaemia in Children
19 The Effect of Retinol Supplement on Blood Cytokine Concentrations in Children with Non-Severe Malaria Vivax
20 Elevated System Energy Expenditure in Sickle Cell Anemia
21 Molecular Basis of Thalassemia
22 Paroxysmal Nocturnal Hemoglobinuria
23 Anemia in Chronic Obstructive Pulmonary Disease
24 An Emerging Face of Fanconi Anemia: Cancer
25 The Molecular Connection Between Aluminum Toxicity, Anemia, Inflammation and Obesity: Therapeutic Cues
26 Hemolysis and Anemia Induced by Dapsone Hydroxy la mine

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Biochemistry and Molecular Biology of Parasites

J. Joseph Marr

ISBN-10: 012390899X

ISBN-13: 978-0123908995

The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms. Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.

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McMinns Color Atlas of Human Anatomy, 5th edition, CD-ROM

Peter H. Abrahams and Ralph T. Hutchings

ISBN-10: 0723432120

ISBN-13: 978-0723432128

This popular atlas maps out the structures of the human body and puts them in a clinical context. It incorporates an unrivalled collection of cadaveric, osteological, and clinical images with surface anatomy models, interpretive drawings, orientational diagrams, and diagnostic images. The 5th Edition features over 50 new dissection photos, many of which are taken from a distance to make them more recognizable in the lab setting. It also offers a more streamlined, user-friendly design, more clinical tips, and a companion CD-ROM with seven anatomical animations.

Displays x-ray, MR, and CT images next to corresponding dissections, teaching readers to recognize anatomic structures in diagnostic images.
Helps readers differentiate between similar structures on specimens (ie. veins, arteries, and nerves) with interpretive drawings.
Offers orientational diagrams that make it easier to relate the dissections in the text to real experiences in the lab.
Provides an unobstructed view of the artwork by using a numbered labeling system, which also allows readers to self-test by covering up the key and identifying each numbered structure.
Includes over 50 new dissections photos, many of which are taken from a distance to make them more recognizable in the lab setting.
Features a redesigned page layout that correlates illustrations, headings, and labels with more clarity.
Uses more distinctly color-coded chapters to improve accessibility.
Makes it easy to locate dissection sites on real life models with 50 new 'locator' images (surface anatomy models).
Adds 20 new clinical tips (300 in all) that are referenced with icons on each page and then listed at the end of each chapter.
Moves the Systemic Review to the front of the book, adding a series of anatomical cross-sections.
Offers a PC and Mac compatible CD-ROM with seven anatomical animations (hand, shoulder, knee, foot, hip, spine, and head & neck) in QuickTime format. Allows users to add and remove layers of skin, muscle, etc.
rotate animations for a complete view from all angles
turn labels on and off to test recognition skills
export images to their hard drive
test themselves with multiple-choice questions linked to each label as well as with a separate quiz function
link to www.fleshandbones.com. Icons in the book refer readers to the animations at appropriate points.

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Understanding Tuberculosis: New Approaches to Fighting Against Drug Resistance, 2012

Understanding Tuberculosis: New Approaches to Fighting Against Drug Resistance"

Pere-Joan Cardona

ISBN: 9533079486

In this book, diverse authors focus on the development and the activity of the new tuberculosis drug families.

In 1957, a Streptomyces strain, the ME/83 (S.mediterranei), was isolated in the Lepetit Research Laboratories from a soil sample collected at a pine arboretum near Saint Raphael, France. This drug was the base for the chemotherapy with Streptomicine. The euphoria generated by the success of this regimen lead to the idea that TB eradication would be possible by the year 2000.

Thus, any further drug development against TB was stopped. Unfortunately, the lack of an accurate administration of these drugs originated the irruption of the drug resistance in Mycobacterium tuberculosis. Once the global emergency was declared in 1993, seeking out new drugs became urgent.

Contents
Preface
Part 1 Strategies for new drug discovering
1 Multi-Drug/Extensively Drug Resistant Tuberculosis (Mdr/Xdr-Tb): Renewed Global Battle Against Tuberculosis?
2 Chemotherapeutic Strategies and Targets Against Resistant TB
3 A New Hope in TB Treatment: The Development of the Newest Drugs
4 In Search of El Dorado: Current Trends and Strategies in the Development of Novel Anti-Tubercular Drugs
5 An Approach to the Search for New Drugs Against Tuberculosis
6 Antitubercular In Vitro Drug Discovery: Tools for Begin the Search
7 New Antitubercular Drugs Designed by Molecular Modification
8 The Cord Factor: Structure, Biosynthesis and Application in Drug Research - Achilles Heel of Mycobacterium tuberculosis?
Part 2 New drugs to face Resistance
9 Old and New TB Drugs: Mechanisms of Action and Resistance
10 Pyrazinecarboxylic Acid Derivatives with Anti mycobacteria I Activity
11 The Potential Therapeutic Usage of Dithiocarbamate Sugar Derivatives for Multi-Drug Resistant Tuberculosis
12 Fighting Against Resistant Strains: The Case of Benzothiazinones and Dinitrobenzamides
13 Quinolone Resistance in Tuberculosis Treatment: A Structural Overview
14 Anti mycobacteria I Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds
15 Cinnamic Derivatives in Tuberculosis
16 Potential Use of I. suffruticosa in Treatment of Tuberculosis with Immune System Activation

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Understanding Tuberculosis: Global Experiences and Innovative Approaches to the Diagnosis

Pere-Joan Cardona

ISBN: 9533079387

This book presents the experience of worldwide specialists on the tuberculosis diagnosis, along with its lights and shadows.

Mycobacterium tuberculosis is a disease that is transmitted through aerosol. This is the reason why it is estimated that a third of humankind is already infected by Mycobacterium tuberculosis. The vast majority of the infected do not know about their status. Mycobacterium tuberculosis is a silent pathogen, causing no symptomatology at all during the infection. In addition, infected people cannot cause further infections. Unfortunately, an estimated 10 per cent of the infected population has the probability to develop the disease, making it very difficult to eradicate. Once in this stage, the bacilli can be transmitted to other persons and the development of clinical symptoms is very progressive.

Therefore the diagnosis, especially the discrimination between infection and disease, is a real challenge.

Contents

Part 1 Experience on Laboratory diagnosis around the World

1 Clinical Laboratory Diagnostics for Mycobacterium tuberculosis

2 Laboratory Diagnosis of Latent and Active Tuberculosis Infections in Trinidad a Tobago and Determination of Drug Susceptibility Profile of Tuberculosis Isolates in the Caribbean

3 Tuberculosis is Still a Major Challenge in Africa

4 Tuberculosis in Saudi Arabia

5 Diagnosis of Mycobacterium tuberculosis

6 Diagnosis of Smear-Negative Pulmonary Tuberculosis in Low-Income Countries: Current Evidence in Sub-Saharan Africa with Special Focus on HIV Infection or AIDS

7 Immunologic Diagnosis of Neurotuberculosis

8 Diagnostic Methods for Mycobacterium tuberculosis and Challenges in Its Detection in India

9 Management of TB in HIV Subjects, the Experience in Thailand

10 Mycobacterium tuberculosis: Biorisk, Biosafety and Biocontainment

Part 2 New approaches to the TB diagnosis

11 New Diagnostics for Mycobacterium tuberculosis

12 Nanodiagnostics for Tuberculosis

13 Sputum Smear Microscopy for Tuberculosis: Evaluation of Autofocus Functions and Automatic Identification of Tuberculosis Mycobacterium

14 The Use of Phage for Detection, Antibiotic Sensitivity Testing and Enumeration

15 Molecular Imaging in TB: From the Bench to the Clinic

16 Data Mining Techniques in the Diagnosis of Tuberculosis

17 Immunological Diagnosis of Active and Latent TB

18 Immune Diagnosis of Tuberculosis Through Novel Technologies

19 Exosomes: New Tuberculosis Bio markers - Prospects From the Bench to the Clinic

20 Molecular Techniques for Identification of Species of the Mycobacterium tuberculosis Complex: The use of Multiplex PCR and an Adapted HPLC Method for Identification of Mycobacterium bovis and Diagnosis of Bovine Tuberculosis

Part 3 Improving detection and control of resistances

21 Survey and Molecular Characterization of Drug- Resistant M. tuberculosis Clinical Isolates from Zunyi, Guizhou Province of China

22 Molecular Biological Techniques for Detection of Multidrug Resistant Tuberculosis (MDR) and Extremely Drug Resistant Tuberculosis (XDR) in Clinical Isolates of Mycobacterium tuberculosis

23 Detection of Mycobacterium tuberculosis and Drug Resistance: Opportunies and Challenges in Morocco

24 Pattern of Circulating Mycobacterium tuberculosis Strains in Sri Lanka

25 Health Interventions to Improve the Medication Efficacy in Tuberculosis Treatment

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